Halal Process Development

Halal Process Development

If any of your current pharmaceutical ingredients or manufacturing processes are not halal compliant, our scientists are ready to pinpoint the non-compliant issues and help you develop an alternative chemical or biological route for a target pharmaceutical product that can be certified Halal. Table below shows a few examples of impermissible materials and their halal alternatives.

Table 1. Impermissible materials used in current production of some pharmaceuticals and their corresponding sharia-compliant alternatives

Types of materials Impermissible materials Alternative materials
Host cell MDCK cell line Duck (EB66, AGE1.CR, DuckCelt-T17) or chick cell lines (PBS-1)
Growth media Serum-containing or animal-component media Serum-free and animal-component- free media
Proteolytic enzyme Porcine trypsin Accutase, trypLE, or religiously slaughtered bovine trypsin
Microcarriers Gelatin-coated microcarriers (FACT III, Cytodex 3, Cultispher S, Cultispher G) Ionic microcarriers (Cytopore 2, Cytoline 2, Cytodex 1)
Stabilizer Porcine or non-slaughtered bovine gelatin (sorbitol, trehalose, inulin, etc.), religiously slaughtered bovine or fish gelatin.
Extracting solvent Ethanol from fermentation Synthetic Ethanol
Gelling agent Porcine-derived gelatin Bovine-derived or fish-derived gelatin
Wound dressings and drug delivery systems Collagen Collagen derived from bovine or marine sources
Cell culture Fetal bovine serum Plant-based or synthetic serum
Lubricant or coating agent Lard or tallow Vegetable-based or synthetic lubricants