Halal Process Development
If any of your current pharmaceutical ingredients or manufacturing processes are not halal compliant, our scientists are ready to pinpoint the non-compliant issues and help you develop an alternative chemical or biological route for a target pharmaceutical product that can be certified Halal. Table below shows a few examples of impermissible materials and their halal alternatives.
Table 1. Impermissible materials used in current production of some pharmaceuticals and their corresponding sharia-compliant alternatives
| Types of materials | Impermissible materials | Alternative materials |
| Host cell | MDCK cell line | Duck (EB66, AGE1.CR, DuckCelt-T17) or chick cell lines (PBS-1) |
| Growth media | Serum-containing or animal-component media | Serum-free and animal-component- free media |
| Proteolytic enzyme | Porcine trypsin | Accutase, trypLE, or religiously slaughtered bovine trypsin |
| Microcarriers | Gelatin-coated microcarriers (FACT III, Cytodex 3, Cultispher S, Cultispher G) | Ionic microcarriers (Cytopore 2, Cytoline 2, Cytodex 1) |
| Stabilizer | Porcine or non-slaughtered bovine gelatin | (sorbitol, trehalose, inulin, etc.), religiously slaughtered bovine or fish gelatin. |
| Extracting solvent | Ethanol from fermentation | Synthetic Ethanol |
| Gelling agent | Porcine-derived gelatin | Bovine-derived or fish-derived gelatin |
| Wound dressings and drug delivery systems | Collagen | Collagen derived from bovine or marine sources |
| Cell culture | Fetal bovine serum | Plant-based or synthetic serum |
| Lubricant or coating agent | Lard or tallow | Vegetable-based or synthetic lubricants |